The Airbus was climbing. Cabin crew told the flight crew that passengers and cabin crew were suffering from significant hypoxia. Hypoxia means inadequate oxygenation of the blood, or deficiency in the amount of oxygen delivered to the body tissues. Web MD says this about hypoxia:
“When your body doesn’t have enough oxygen, you could get hypoxemia or hypoxia. These are dangerous conditions. Without oxygen, your brain, liver, and other organs can be damaged just minutes after symptoms start.”
“Hypoxemia (low oxygen in your blood) can cause hypoxia (low oxygen in your tissues) when your blood doesn’t carry enough oxygen to your tissues to meet your body’s needs. The word hypoxia is sometimes used to describe both problems. Symptoms can vary from person to person, the most common hypoxia symptoms are Changes in the color of your skin, ranging from blue to cherry red, Confusion,Cough, Fast heart rate, Rapid breathing, Shortness of breath, Sweating, Wheezing. If you have symptoms of hypoxia, call 911.”
On the Tam flight in question, the flight crew manually released the passenger oxygen masks. After returning to Brasilia, the incident was rated serious. CENIPA is investigating. CENIPA’s acronym is in Portuguese: Centro de Investigação e Prevenção de Acidentes Aeronáuticos. CENIPA is a unit of the Brazilian Air Force that investigates aviation accidents and incidents in Brazil.
The flight under investigation was JJ-3538 flown by the Airbus registered as #PR-MAA on a standard flight from Brasilia,DF to Aracaju, SE in Brazil.

Serious incident, Brasilia Federal District, on 18 January 2016, AIRBUS – A320, PR-MAA; click to enlarge image